"The 5-year survival rate for liver cancer that is localized to the liver is approximately 33%. Those with distant spread of the disease have a 5- year survival rate of only 2%."



The most common tests that will be done to help diagnose liver cancer (in addition to a thorough history and physical exam) are:

  • Ultrasound Abdomen
  • Triphasic contrast-enhanced CT scan of the abdomen
  • Multiphasic contrast-enhanced MRI scan
  • PET-CT scan
  • Tumour markers like levels of serum alpha-fetoprotein.
  • Blood tests for levels of serum bilirubin, serum albumin, liver enzymes such as alanine transaminase, aspartate transaminase, alkaline phosphatase.



Various treatment options for liver cancer include:

  • Liver transplant - this involves removing the entire diseased liver and replacing it with a donor liver (or part thereof) from another person (either living or deceased).
  • Liver resection - surgery to remove the part of the liver with the liver cancer.
  • Interventional Radiology procedures - such as transarterial chemoembolization (TACE) in which chemotherapy is injected into the blood vessel supplying the cancerous tumor, transarterialradioembolization (TARE) in which radioactive beads are injected into the feeding blood vessel, radiofrequency ablation (RFA) and microwave ablation (MWA) where thermal energy is used to ablate/burn the tumour.
  • Stereotactic body radiation therapy - is a form of external beam radiation, usually delivered with X-rays/photons to ablate the liver cancer.
  • Proton beam therapy - where beams of protons are focused to ablate the liver cancer.
  • Chemotherapy - targeted therapy drugs such as Sorafenib, Regorafenib, Lenvatinib are used to control disease both within and outside the liver.
  • Immunotherapy - newer medicines that manipulate the body’s immune system to fight the cancer cells, such as Nivolumab, Atezolizumab and others are used to control advanced liver cancer.

Proton Therapy

Radiation in the form of stereotactic body radiotherapy (SBRT) has a role in treating both early-stage hepatocellular carcinomas (HCC), who are ineligible or fail other liver-directed therapies, as well as unresectable HCC. In cholangiocarcinomas and liver metastases from other cancers also, SBRT has been successfully used to deliver high doses to the tumour. In all three of these situations, proton therapy has a role in delivering higher doses to the tumour, while protecting the remaining normal liver from damage. This helps to increase the rate of control of the tumour while reducing the chances of radiation-induced damage to the liver. Radiation therapy is also used with palliative intent to relieve local pain.

Winning Over Cancer

Dr. Ashwathy Mathew, Consultant - Radiation Oncologist at APCC and our expert in Gastrointestinal oncology explains how Proton therapy is an effective treatment in Gastrointestinal cancers.


Welcoming Dr Bhawna Sirohi. Dr. Bhawna Sirohi is a leading Medical Oncologist with an exemplary experience of more than 25 years. She is a renowned senior consultant across the globe who specializes in treating Breast Oncology and Gastrointestinal Cancers.

Dr. Bhawna has worked with the top Oncology Centres & Oncologists around the world. She joins as the Lead – Medical Oncologist at Apollo Proton Cancer Centre.


Dr. Smarajit Patnaik from Bhubaneswar underwent proton therapy at Apollo proton cancer centre under the guidance of Dr. Ashwathy, Radiation Oncologist, APCC. Dr Smarajit Patnaik says "Thank you for making me feel safe & comfortable and taking utmost care during COVID-19". He also appreciated the quick action taken by the doctors & the professional & warm environment in the hospital.


Dr. Bhawna Sirohi, Lead - Medical Oncologist at APCC, who specializes in GI Cancers talks about Pancreatic Cancer in this video. She outlines the risk factors, symptoms and the way forward for testing & treatment associated with this specific disease.


Other Gastrointestinal Cancers