Globally, Esophageal cancer is the eighth most common cancer with an annual incidence of 572000 new cases. In India, the annual incidence of new cases is about 52,396, and is the fourth most common cause of cancer-related deaths. There has been a significant increase in the incidence of esophageal cancers worldwide, with reports showing a higher incidence of adenocarcinoma in countries with a higher human development index (HDI). For example, in the United States, the incidence of adenocarcinoma of esophagus has increased by about 400% over the past 25 years, and in contrast, in countries like India, the incidence of esophageal squamous cell carcinoma is still more common. The reported deaths in India per year is approximately about 42000.